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Avilamycin (AVI) - Medicating Ingredient Brochure

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Status: Veterinary prescription required for approved claims

Revised April 2020

Table of approved species and claims
Approved livestock species Approved claim(s)
(abbreviated) Table Note 1
Withdrawal time Name of approved brand(s)
Broiler chickens
  1. Prevention of necrotic enteritis
0 days Surmax Premix
Swine
  1. Reduction in incidence and severity of post-weaning diarrhea
0 days Surmax Premix

Table Note

Table Note 1

In order to be compliant with the Feeds Regulations, the complete claim must appear on the medicated feed label.

Return to table note 1  referrer

Broiler chickens

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claim 1 Surmax Premix Avilamycin at 100 g/kg

Claim 1

For the prevention of necrotic enteritis caused by Clostridium perfringens in growing broiler chickens.

Level of medicating ingredient in a complete feed

15 to 30 mg/kg (0.0015 to 0.003%) of avilamycin in the complete feed.

Directions for use in a complete feed

This livestock feed contains an antibiotic that has yet to be categorized and hence is potentially medically important. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently.

This medicated feed containing avilamycin at 15 to 30 mg/kg (ppm) should be fed as the sole ration continuously for a period of 21 days during the period of risk of necrotic enteritis, as determined by the veterinarian.

Additional information (not to appear on feed labels)

For feed manufacturers
  • Feed labels must state one specific drug level.
  • Thoroughly mix 0.15 to 0.30 kg of Surmax Premix per 1000 kg of feed to yield 15 to 30 mg/kg (ppm) of avilamycin.
  • For better dispersion, it is recommended that the Surmax Premix be thoroughly mixed with a small quantity of the feed ingredients (totalling at least 10 kg) prior to the manufacturing of the medicated feed.

Warning

  1. No withdrawal period is required for broiler chickens when treated at the recommended dose of 15 to 30 mg/kg (ppm) for a period of 21 days during the period of risk of necrotic enteritis.
  2. Do not use in feeds for laying hens.
  3. Avoid inhalation, oral exposure, and direct contact with skin or eyes. Operators mixing and handling avilamycin should use protective clothing, impervious gloves, goggles, and an approved dust mask. Wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. If irritation persists, seek medical attention. (Required on premix and supplement labels only)
  4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Do not use in feeds containing pellet binding agents with the exception of calcium lignosulfate pellet binder. (Required on premix and supplement labels only)

Additional information to be added as notes to feed labels

Notes

  • Must be thoroughly mixed in broiler feeds before use. (Required on premix and supplement labels only)
  • Comprehensive necrotic enteritis management should be planned in consultation with veterinary and nutritional poultry expertise, and based on flock health history and exposure to necrotic enteritis risk factors.
  • "Fed as the sole ration" may refer to a single medicated feed that is fed for the entire 21-day treatment period or, in the case of phase-feeding programs, different medicated feeds containing avilamycin at the approved level of drug that are fed sequentially during the 21-day treatment period (e.g., pre-starter, starter, grower, finisher), as part of the production program.

Accepted Compatibilities

Avilamycin is compatible with the following drugs/drug combinations. In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For details, refer to the MIB as indicated.

Avilamycin (broiler chickens)
Name of medicating ingredient MIB code Name of approved brand(s) Applicable claims
Narasin NAR
  • Monteban 100 Premix
Claim 1
Narasin and Nicarbazin NRNC Maxiban Premix All claims

Swine

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claim 1 Surmax Premix Avilamycin at 100 g/kg

Claim 1

For the reduction in incidence and severity of post-weaning diarrhea associated with Escherichia coli in pigs. Avilamycin is to be used in pigs that are at risk of developing, but not yet showing clinical signs of, diarrhea in the presence of pathogenic E. coli.

Level of medicating ingredient in a complete feed

80 mg/kg (0.008%) of avilamycin in the complete feed.

Directions for use in a complete feed

This livestock feed contains an antibiotic that has yet to be categorized and hence is potentially medically important. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently.

This medicated feed containing avilamycin at 80 mg/kg (ppm) should be fed as the sole ration continuously for a period of up to 21 days post-weaning, and prior to the expected onset of post-weaning diarrhea, as determined by the veterinarian.

Additional information (not to appear on feed labels)

For feed manufacturers
  • Thoroughly mix 0.80 kg of Surmax Premix per 1000 kg of feed to yield 80 mg/kg (ppm) of avilamycin.
  • For better dispersion, it is recommended that Surmax Premix be thoroughly mixed with a small quantity of feed ingredients (totalling at least 10 kg) prior to the manufacturing of the medicated feed.

Warning

  1. No withdrawal period is required for swine when treated at the recommended dose of 80 mg/kg (ppm) for a period of up to 21 days post-weaning.
  2. Avoid inhalation, oral exposure, and direct contact with skin or eyes. Operators mixing and handling avilamycin should use protective clothing, impervious gloves, goggles, and an approved dust mask. Wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. If irritation persists, seek medical attention. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Do not use in feeds containing pellet binding agents with the exception of calcium lignosulfate pellet binder. (Required on premix and supplement labels only)
  2. The effectiveness of avilamycin has only been demonstrated when avilamycin-medicated feed was offered before the onset of diarrhea. Use of avilamycin for the treatment of established cases of clinical diarrhea in weanling pigs has not been demonstrated.

Additional information to be added as notes to feed labels

Notes

  • Must be thoroughly mixed in swine feeds before use. (Required on premix and supplement labels only)
  • Comprehensive management of diarrhea due to E. coli should be planned in consultation with veterinary and nutritional swine expertise.
  • As avilamycin is only indicated for use in weanling pigs, responsible antimicrobial use limits its use to pigs less than 14 weeks of age.
  • "Fed as the sole ration" may refer to a single medicated feed that is fed for the entire 21-day treatment period or, in the case of phase-feeding programs, different medicated feeds containing avilamycin at the approved level of drug that are fed sequentially during the 21-day treatment period (e.g., pre-starter, starter, grower, finisher), as part of the production program.

Accepted Compatibilities

Nil