Tylosin (TYL) - Medicating Ingredient Brochure

Status: Veterinary prescription required for approved claims

Revised October 2022

Broiler chickens

Claim 1

As an aid in the treatment of necrotic enteritis caused by Clostridium perfringens in broiler chickens.

Level of medicating ingredient in the complete feed

200 mg/kg (0.02%) of tylosin in the complete feed.

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed as the sole ration for 7 days.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and thoroughly mix into the ration at the following rate to provide 200 mg/kg (0.02%) tylosin per metric tonne (1,000 kg) of finished (complete) feed:

• 2.27 kg of the Pharmasin 40, Tylan 40 or Tylosin 40 Tylosin Phosphate Premixes; or
• 0.91 kg (910 g) of the Tylan 100, Tylosin 100, or Pharmasin 100 Tylosin Phosphate Premixes

Warning

1. No preslaughter withdrawal period is required for broiler chickens when fed this medicated feed at the recommended level of 200 mg/kg (0.02%) tylosin in the complete feed.
2. Do not use in laying hens.
3. This product may be irritating to skin and mucous membranes. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes. Use protective clothing, impervious gloves and a dust mask. (Required on premix and supplement labels only)
4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

1. Not to be used in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). Do not use in any supplement, concentrate or complete feed containing bentonite. Not for use in thixotropic liquid supplements. (Required on premix and supplement labels only)
2. When treating necrotic enteritis, the diagnosis should be re-determined in cases of lack of response within 3 to 5 days of treatment commencement.

Accepted Compatibilities

Tylosin is compatible in single combination with the following drugs. In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For details, refer to the MIB as indicated.

Swine

Claim 1

As an aid in the treatment and the prevention of cyclic recurrence of swine dysentery (bloody scours, bloody diarrhea, black scours, hemorrhagic colitis, vibrio).

Level of medicating ingredient in the complete feed

1. Treatment: 110 mg/kg (0.011%) of tylosin in the complete feed.
2. Prevention following Treatment: 44 mg/kg (0.0044%) of tylosin in the complete feed.

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

1. Treatment: Feed the treatment dose (110 mg/kg) for 3 weeks. Tylosin-medicated drinking water should be provided concurrently for the first 3 days of treatment, or until symptoms disappear.
2. Prevention following Treatment: To prevent recurrence of swine dysentery, feed the prevention dose (44 mg/kg) as the sole ration until animals reach market weight.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and thoroughly mix into the ration at the following rate to provide 110 mg/kg (0.011%) tylosin per metric tonne (1,000 kg) of finished (complete) feed:

• 5.0 kg of the Tylosin 10 Tylosin Phosphate Premix; or
• 1.25 kg of the Pharmasin 40, Tylan 40 or Tylosin 40 Tylosin Phosphate Premixes; or
• 0.5 kg (500 g) of the Tylan 100, Pharmasin 100 or Tylosin 100 Tylosin Phosphate Premixes

Add and thoroughly mix into the ration at the following rate to provide 44 mg/kg (0.0044%) tylosin per metric tonne (1,000 kg) of finished (complete) feed:

• 2.0 kg of the Tylosin 10 Tylosin Phosphate Premix; or
• 0.5 kg (500 g) of the Pharmasin 40, Tylan 40 or Tylosin 40 Tylosin Phosphate Premixes; or
• 0.2 kg (200 g) of the Tylan 100, Pharmasin 100 or Tylosin 100 Tylosin Phosphate Premixes

Warning

1. Swine treated concurrently with this drug in complete feed and with tylosin tartrate in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.
2. No preslaughter withdrawal period is required when swine are treated with this drug at a level of 44 mg/kg (0.0044%) or 110 mg/kg (0.011%) of tylosin in the complete feed except when used concurrently with tylosin in drinking water.
3. This product may be irritating to skin and mucous membranes. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes. Use protective clothing, impervious gloves and a dust mask. (Required on premix and supplement labels only)
4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

1. In rare cases, edema of the rectal mucosa and mild anal protrusion with pruritis, erythema and diarrhea have been reported in pigs consuming this drug in feed.
2. Not to be used in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). Do not use in any supplement, concentrate or complete feed containing bentonite. Not for use in thixotropic liquid supplements. (Required on premix and supplement labels only)
3. When treating swine dysentery, the diagnosis should be redetermined in cases of lack of response within 3 to 5 days of treatment commencement.

Claim 2

For use as an aid in the prevention of porcine proliferative enteropathy (PPE) or ileitis associated with Lawsonia intracellularis.

Level of medicating ingredient in the complete feed

110 mg/kg (0.011%) of tylosin in the complete feed.

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed as the sole ration for 21 days, commencing prior to an anticipated outbreak of disease.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and thoroughly mix into the ration at the following rate to provide 110 mg/kg (0.011%) tylosin per metric tonne (1,000 kg) of finished (complete) feed:

• 5.0 kg of the Tylosin 10 Tylosin Phosphate Premix; or
• 1.25 kg of the Pharmasin 40, Tylan 40 or Tylosin 40 Tylosin Phosphate Premixes; or
• 0.5 kg (500 g) of the Tylan 100, Pharmasin 100 or Tylosin 100 Tylosin Phosphate Premixes

Warning

1. Swine treated concurrently with this drug in complete feed and with tylosin tartrate in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.
2. No preslaughter withdrawal period is required when swine are treated with this drug at a level of 110 mg/kg (0.011%) of tylosin in the complete feed except when used concurrently with tylosin in drinking water.
3. This product may be irritating to skin and mucous membranes. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes. Use protective clothing, impervious gloves and a dust mask. (Required on premix and supplement labels only)
4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

1. In rare cases, edema of the rectal mucosa and mild anal protrusion with pruritis, erythema and diarrhea have been reported in pigs consuming this drug in feed.
2. Not to be used in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). Do not use in any supplement, concentrate or complete feed containing bentonite. Not for use in thixotropic liquid supplements. (Required on premix and supplement labels only)
3. When treating porcine proliferative enteropathy (PPE) or ileitis, the diagnosis should be confirmed when results are not satisfactory.

Claim 3

As an aid in the treatment of porcine proliferative enteropathy (PPE) or ileitis associated with Lawsonia intracellularis when used following treatment with tylosin soluble powder.

Level of medicating ingredient in the complete feed

110 mg/kg (0.011%) of tylosin in the complete feed.

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed as the sole ration for 7 days, following a 7-day treatment of tylosin-medicated drinking water.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and thoroughly mix into the ration at the following rate to provide 110 mg/kg (0.011%) tylosin per metric tonne (1,000 kg) of finished (complete) feed:

• 1.25 kg of the Pharmasin 40, Tylan 40 or Tylosin 40 Tylosin Phosphate Premixes; or
• 0.5 kg (500 g) of the Tylan 100, Pharmasin 100 or Tylosin 100 Tylosin Phosphate Premixes

Warning

1. Swine treated concurrently with this drug in complete feed and with tylosin tartrate in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.
2. No preslaughter withdrawal period is required when swine are treated with this drug at a level of 110 mg/kg (0.011%) of tylosin in the complete feed except when used concurrently with tylosin in drinking water.
3. This product may be irritating to skin and mucous membranes. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes. Use protective clothing, impervious gloves and a dust mask. (Required on premix and supplement labels only)
4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

1. In rare cases, edema of the rectal mucosa and mild anal protrusion with pruritis, erythema and diarrhea have been reported in pigs consuming this drug in feed.
2. Not to be used in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). Do not use in any supplement, concentrate or complete feed containing bentonite. Not for use in thixotropic liquid supplements. (Required on premix and supplement labels only)
3. When treating porcine proliferative enteropathy (PPE) or ileitis, the diagnosis should be confirmed when results are not satisfactory.

Claim 4

For the treatment of porcine proliferative enteropathy (PPE) or ileitis associated with Lawsonia intracellularis.

Level of medicating ingredient in the complete feed

110 mg/kg (0.011%) of tylosin in the complete feed.

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed as the sole ration for 3 weeks.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and thoroughly mix into the ration at the following rate to provide 110 mg/kg (0.011%) tylosin per metric tonne (1,000 kg) of finished (complete) feed:

• 1.25 kg of the Pharmasin 40, Tylan 40 or Tylosin 40 Tylosin Phosphate Premixes; or
• 0.5 kg (500 g) of the Tylan 100, Pharmasin 100 or Tylosin 100 Tylosin Phosphate Premixes

Warning

1. Swine treated concurrently with this drug in complete feed and with tylosin tartrate in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.
2. No preslaughter withdrawal period is required when swine are treated with this drug at a level of 110 mg/kg (0.011%) of tylosin in the complete feed except when used concurrently with tylosin in drinking water.
3. This product may be irritating to skin and mucous membranes. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes. Use protective clothing, impervious gloves and a dust mask. (Required on premix and supplement labels only)
4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

1. In rare cases, edema of the rectal mucosa and mild anal protrusion with pruritis, erythema and diarrhea have been reported in pigs consuming this drug in feed.
2. Not to be used in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). Do not use in any supplement, concentrate or complete feed containing bentonite. Not for use in thixotropic liquid supplements. (Required on premix and supplement labels only)
3. When treating porcine proliferative enteropathy (PPE) or ileitis, the diagnosis should be confirmed when results are not satisfactory.

Claim 5

For the treatment of porcine proliferative enteropathy (PPE) or ileitis associated with Lawsonia intracellularis in the presence of persistent or recurring infection.

Level of medicating ingredient in the complete feed

1. Treatment in the presence of persistent or recurring infection: Feed the treatment dose 110 mg/kg (0.011%) of tylosin in the complete feed
2. Prevention of Recurrence: 44 mg/kg of tylosin in complete feed.

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed the medicated feed with the treatment dose of 110 mg/kg (0.011%) of tylosin as the sole ration for 3 weeks. This must be followed by a medicated feed with the dose of 44 mg/kg (0.0044%) of tylosin to prevent recurrence for the next 3 weeks.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and thoroughly mix into the ration at the following rate to provide 110 mg/kg (0.011%) tylosin per metric tonne (1,000 kg) of finished (complete) feed:

• 1.25 kg of the Pharmasin 40, Tylan 40 or Tylosin 40 Tylosin Phosphate Premixes; or
• 0.5 kg (500 g) of the Tylan 100, Pharmasin 100 or Tylosin 100 Tylosin Phosphate Premixes

Add and thoroughly mix into the ration at the following rate to provide 44 mg/kg (0.0044%) tylosin per metric tonne (1,000 kg) of finished (complete) feed:

• 0.5 kg (500 g) of the Pharmasin 40, Tylan 40 or Tylosin 40 Tylosin Phosphate Premixes; or
• 0.2 kg (200 g) of the Tylan 100, Pharmasin 100 or Tylosin 100 Tylosin Phosphate Premixes

Warning

1. Swine treated concurrently with this drug in complete feed and with tylosin tartrate in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.
2. No preslaughter withdrawal period is required when swine are treated with this drug at a level of 44 mg/kg (0.0044%) or 110 mg/kg (0.011%) of tylosin in the complete feed except when used concurrently with tylosin in drinking water.
3. This product may be irritating to skin and mucous membranes. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes. Use protective clothing, impervious gloves and a dust mask. (Required on premix and supplement labels only)
4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

1. In rare cases, edema of the rectal mucosa and mild anal protrusion with pruritis, erythema and diarrhea have been reported in pigs consuming this drug in feed.
2. Not to be used in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). Do not use in any supplement, concentrate or complete feed containing bentonite. Not for use in thixotropic liquid supplements. (Required on premix and supplement labels only)
3. When treating porcine proliferative enteropathy (PPE) or ileitis, the diagnosis should be confirmed when results are not satisfactory.

Claim 6

For use as an aid in the prevention of subclinical porcine proliferative enteropathy (PPE) or ileitis associated with Lawsonia intracellularis.

Level of medicating ingredient in the complete feed

44 mg/kg (0.0044%) of tylosin in the complete feed.

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed as the sole ration for 21 days, commencing prior to an anticipated subclinical manifestation of the disease. The best time to initiate medication should be determined by a veterinarian based on the use of appropriate diagnostic tools.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and thoroughly mix into the ration at the following rate to provide 44 mg/kg (0.0044%) tylosin per metric tonne (1,000 kg) of finished (complete) feed:

• 0.5 kg (500 g) of the Tylan 40 Tylosin Phosphate Premix; or
• 0.2 kg (200 g) of the Tylan 100 Tylosin Phosphate Premix

Warning

1. Swine treated concurrently with this drug in complete feed and with tylosin tartrate in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.
2. No preslaughter withdrawal period is required when swine are treated with this drug at a level of 44 mg/kg (0.0044%) of tylosin in the complete feed except when used concurrently with tylosin in drinking water.
3. This product may be irritating to skin and mucous membranes. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes. Use protective clothing, impervious gloves and a dust mask. (Required on premix and supplement labels only)
4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

1. In rare cases, edema of the rectal mucosa and mild anal protrusion with pruritis, erythema and diarrhea have been reported in pigs consuming this drug in feed.
2. Not to be used in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). Do not use in any supplement, concentrate or complete feed containing bentonite. Not for use in thixotropic liquid supplements. (Required on premix and supplement labels only)
3. When treating porcine proliferative enteropathy (PPE) or ileitis, the diagnosis should be confirmed when results are not satisfactory.

Accepted Compatibilities

Nil

Beef cattle

Claim 1

To reduce the incidence of liver abscesses caused by Trueperella pyogenes and Fusobacterium necrophorum in beef cattle (steers and heifers) fed in confinement for slaughter.

Level of medicating ingredient in the complete diet

11 mg/kg (0.0011%) of tylosin in the complete diet including roughage (100% dry matter basis).

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed continuously as the sole ration.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and thoroughly mix into the ration at the following rate to provide 11 mg/kg (0.0011%) tylosin in the complete diet including roughage (100% dry matter basis):

• 0.5 kg (500 g) of the Tylosin 10 Tylosin Phosphate Premix; or
• 0.125 kg (125 g) of the Pharmasin 40, Tylan 40 or Tylosin 40 Tylosin Phosphate Premixes; or
• 0.05 kg (50 g) of the Tylan 100, Pharmasin 100 or Tylosin 100 Tylosin Phosphate Premixes

Note:

1. Pharmasin 40 and Pharmasin 100 can be used in the following thixotropic liquid supplements: HCS, Nutrena Feeds, Cargill Limited and Promolas Liquid Supplement Suspension, Westway Feed Products.
2. Tylan 40 and Tylan 100 can be used in the following thixotropic liquid supplement: Promolas Liquid Supplement Suspension, Westway Feed Products, as well as with monensin.
3. The use of pellet binders may be limited to Agri-Colloid when feeds include both monensin and tylosin, according to the accepted compatibility, due to their respective Caution statements.

Warning

1. Do not use in lactating dairy cattle.
2. No preslaughter withdrawal periods are required for beef cattle when fed this medicated feed at the recommended level of 11 mg/kg (0.0011%) tylosin in complete feed.
3. This product may be irritating to human skin and mucous membranes. When mixing and handling this premix, avoid inhalation, oral exposure and direct contact with skin or eyes. Use protective clothing, impervious gloves, and a dust mask. (Required on premix and supplement labels only)
4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

1. Do not use in replacement, breeding, or lactating cattle.
2. Not to be used in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). Do not use in any supplement, concentrate or complete feed containing bentonite. May be used in a thixotropic liquid supplement with monensin. (Required on premix and supplement labels only)
3. Do not use the thixotropic supplement after 8 weeks storage. (Required on Promolas Liquid Supplement Suspension and Westway Feed Products thixotropic liquid supplement labels only)

Accepted Compatibilities

Tylosin is compatible in single combination with the following drugs. In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For details, refer to the MIB as indicated.

Tylosin is compatible with multiple drugs in the following combinations (feedlot heifers only). In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For details, refer to the MIB as indicated.