Zilpaterol hydrochloride (ZIL) - Medicating Ingredient Brochure
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Status: Over the counter
Date of revision: July 2015
|Approved livestock species||Approved claim(s)
(abbreviated) Table Note 1
|Withdrawal time||Name of
|Beef cattle (weighing at least 450 kg body weight fed in confinement for slaughter)||
||4 days (meat)||Zilmax Premix|
- Table Note 1
In order to be compliant with the Feeds Regulations, the complete claim must appear on the medicated feed label.
Beef cattle (weighing at least 450 kg body weight fed in confinement for slaughter)
|Approved claims||Name of
|Drug concentration in
|Claim 1||Zilmax Premix||zilpaterol hydrochloride at 48 g/kg|
Approved for use in meal or pellet feed
For increased carcass leanness, increased dressing percent, improved rate of body weight gain and improved feed efficiency in beef cattle weighing at least 450 kg fed in confinement for slaughter during the last 20 - 40 days on feed.
Level of Drug in the total diet
8.3 mg/kg (0.00083%) of zilpaterol hydrochloride in the total diet to provide 60 to 90 mg/head/day.
Note (not required to appear on medicated feed labels)
- Total diet refers to the complete feed, supplements, premixes and/or grains plus the roughage and must be corrected to a 100% dry matter basis.
|Weight of cattle (kg)||Dry matter intake (DMI) of the total diet (kg/head/day) Table Note 2||Zilpaterol hydrochloride consumed (mg/head/day) Table Note 3|
|600||10.8 Table Note 4||89.64|
- Table Note 2
assuming ad libitum dry matter intake of the total diet at 1.8% of the cattle weight
- Table Note 3
Refer to Example A below for the calculation of the concentration of zilpaterol hydrochloride in the premix or supplement to provide 8.3 mg/kg of zilpaterol hydrochloride in the total diet.
- Table Note 4
10.8 kg of dry matter intake/head/day is the maximum daily total diet intake allowed for this feeding method.
Level of drug delivered in a medicated component feed at:
60 mg/head/day of zilpaterol hydrochloride
Note: Medicated component feed refers to the portion of the total daily feed intake (total mixed ration) that is medicated with zilpaterol hydrochloride and which has been formulated into a premix or supplement to deliver the recommended daily dose of 60 mg zilpaterol hydrochloride per head per day. For example, the premix or supplement medicated with zilpaterol hydrochloride delivering the total daily dose of 60 mg is added to the total ration in either the first or second feeding, with all other daily feedings being not medicated.
|Example of total daily dry matter intake Table Note 5(kg/head/day)||Example of dry matter intake of medicated component feed fed in a single meal (kg/head) Table Note 5 Table Note 6||Example of medicated premix or supplement (kg) formulated to deliver 60 mg of zilpaterol hydrochloride/head/day and added to the medicated component feed (kg/head/day)||Concentration of zilpaterol hydrochloride in the medicated premix or supplement Table Note 7 (mg/kg)||Concentration of zilpaterol hydrochloride in the medicated component feed fed in a single meal (mg/kg)|
|13.5||7.23 (53.5%) Table Note 6 Table Note 8||0.25||240||8.3|
|12.5||6.25 (50%) Table Note 8||0.2||300||9.6|
|11.0||4.4 (40%) Table Note 8||0.15||400||13.64|
|10.0||3.5 (35%) Table Note 8||0.1||600||17.14|
- Table Note 5
based on 100% dry matter basis
- Table Note 6
7.23 kg is the maximum dry matter intake allowed to be fed in a medicated component feed.
- Table Note 7
Refer to Example B below for the calculation of the concentration of zilpaterol hydrochloride in the premix or supplement.
- Table Note 8
Based on (xx %) of the total daily dry matter intake delivered as a single feeding.
Mix the medicated supplement or medicated premix in the total diet or in the component feed so that when used as directed, the approved level of drug will be supplied.
Zilmax Premix can be used in liquid supplements under the following conditions:
- liquid supplements should be in a pH range of 3.8 - 7.5
- liquid supplements should be agitated daily, and prior to use, for 10 - 20 minutes
- liquid supplements may contain zilpaterol hydrochloride at a level of 83 - 830 g/tonne.
Feed the medicated premix or supplement to beef cattle weighing at least 450 kg fed in confinement for slaughter for the last 20 to 40 consecutive days at the end of the feeding period.
For zilpaterol hydrochloride supplied at 8.3 mg/kg of the total diet:
Feed continuously in the total diet as a sole ration to beef cattle consuming a maximum of 10.8 kg of dry matter intake /head/day. Note that feed labels will also be required to state the expected dry matter intake of the cattle when the approved level of drug is calculated based on the DMI of the total diet.
For zilpaterol hydrochloride supplied at 60 mg/head/day in a medicated component feed:
Add the medicated premix or supplement to a portion of the total daily ration in one of multiple daily feeding (e.g. first or second feeding) for which the maximum dry matter intake of this medicated meal does not exceed 7.23 kg/head. All other daily feedings are not medicated.
To ensure proper mixing, the medicated supplement, premix or component feed should first be diluted with grain or supplement in an intermediate blending step prior to adding to the final blend of the total diet and be mixed thoroughly before use.
Do not feed as top dressing.
Do not feed undiluted.
The following calculations can be used to assist in determining:
Example A: The level of zilpaterol hydrochloride required in supplement or premix to meet the approved level of drug in the total diet when total dry matter intake does not exceed 10.8 kg per head per day:
Example: 8.3 mg of zilpaterol hydrochloride/kg total diet X 9.9 kg dry matter intake of the total diet/head/day ÷ 0.5 kg of medicated supplement or premix/head/day = 164.34 mg/kg or 164.34 g of zilpaterol hydrochloride/tonne of medicated supplement or premix.
Example B: Zilpaterol hydrochloride at 60 mg/head/day supplied by a premix or supplement and fed in the medicated component feed when the meal does not exceed 7.23 kg of dry matter intake per head. Other daily meals fed to cattle are not medicated.
Example: 60 mg zilpaterol hydrochloride/head/day ÷ 0.25 kg premix or supplement fed in the medicated component feed/head/day = 240 mg/kg or 240 g of zilpaterol hydrochloride/tonne of premix or supplement.
- Treated animals must not be slaughtered for use in food for at least four (4) days after the latest treatment with this medicated feed.
- Do not use in lactating dairy cattle.
- Do not feed to calves to be processed for veal.
- Zilpaterol hydrochloride is a beta2-adrenergic agonist. Individuals with cardiovascular disease should exercise special caution to avoid exposure to this medicated feed. (Required on premix and supplement labels only)
- Keep out of reach of children. (Required on premix and supplement labels only)
- Do not feed to male or female cattle intended for reproduction.
- Do not allow horses or other equines access to this medicated feed.
- Do not feed to cattle in excess of 90 mg/head/day in the total diet. If pen consumption of the total diet exceeds 10.8 kg/head/day (100% dry matter basis), zilpaterol hydrochloride should not be fed in the total diet.
- Animals receiving zilpaterol hydrochloride may exhibit an increased respiratory rate as well as elevated levels of creatine phosphokinase (CPK) and creatinine.
- Recirculate or agitate daily, and prior to use, for 10 - 20 minutes. (liquid supplement labels only)
- Date modified: