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Tiamulin (TIA) – Medicating Ingredient Brochure

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Status: Veterinary prescription required for approved claims

Date of revision: February 2021

Table of approved species and claims
Approved livestock species Approved claim(s)
(abbreviated) Table Note 1
Withdrawal time Name of approved brand(s)
Swine 1. Prevention of swine dysentery 2 days
(meat)
  1. Denagard Medicated Premix
  2. Tiamulin 1.78% Medicated Premix
  3. Denagard 10% GF Premix
  4. Tiamulin HF 10% Premix
  5. Vetmulin Premix
  6. Vetmulin 10% Premix
Swine 2. Treatment of swine dysentery 7 days
(meat)
  1. Denagard Medicated Premix
  2. Tiamulin 1.78% Medicated Premix
  3. Denagard 10% GF Premix
  4. Tiamulin HF 10% Premix
  5. Vetmulin Premix
  6. Vetmulin 10% Premix
Swine 3. Treatment of Porcine Colonic Spirochaetosis
4. Treatment of Porcine Proliferative Enteropathy
5. Treatment of Enzootic Pneumonia
7 days
(meat)
  1. Denagard 10% GF Premix
  2. Tiamulin HF 10% Premix
  3. Vetmulin 10% Premix

Swine

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claims
1, 2
1. Denagard Medicated Premix
2. Tiamulin 1.78% Medicated Premix
3. Vetmulin Premix
17.8 g/kg of tiamulin base
(equivalent to 22 g/kg tiamulin hydrogen fumarate)
Claims
1, 2
4. Denagard 10% GF Premix
5. Tiamulin HF 10% Premix
6. Vetmulin 10% Premix
80.91 g/kg of tiamulin base
(equivalent to 100 g/kg of tiamulin hydrogen fumarate)
Claims
3, 4, 5
1. Denagard 10% GF Premix
2. Tiamulin HF 10% Premix
3. Vetmulin 10% Premix
80.91 g/kg of tiamulin base
(equivalent to 100 g/kg of tiamulin hydrogen fumarate)

Claim 1

For the prevention of swine dysentery associated with Brachyspira hyodysenteriae susceptible to tiamulin.

Level of medicating ingredient in a complete feed

31.2 mg/kg (0.00312%) of tiamulin base in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed continuously as the sole ration to swine on premises with a history of swine dysentery but where signs of disease have not yet occurred. Feed continuously to prevent reinfection following use of tiamulin at 178.1 mg/kg (0.01781%) tiamulin base for 14 days or following use of tiamulin medicated drinking water for treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae during the risk period of 6 to 8 weeks.

Additional information (not to appear on feed labels)

For feed manufacturers

Add and thoroughly mix into the ration at the following rate to provide 31.2 mg/kg (0.00312%) tiamulin base per metric tonne (1000 kg) of finished (complete) feed:

Warning

  1. Treated animals must not be slaughtered for use in food for at least 2 days after the latest treatment with this medicated feed at 31.2 mg/kg (0.00312%) of tiamulin base in the complete feed.
  2. When mixing, direct contact with the skin and eyes should be avoided by wearing impermeable rubber gloves and safety glasses. In case of accidental eye contact, irrigate the eyes thoroughly with clean running water immediately. Seek medical advice if irritation persists. When handling the product, inhalation of the dust must be avoided by wearing a disposable half-mask respirator. Contaminated clothing should be removed and any splashes on to the skin should be washed off immediately. Wash hands after use. In case of accidental ingestion, seek medical advice immediately and show the label to the physician. (Required on premix and supplement labels only).
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Overdoses of tiamulin have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. In very rare cases, death has been reported.
  2. In rare cases, redness of the skin, primarily over the ham and underline, has been observed during medication.
  3. If signs of toxicity or redness of the skin occurs, promptly discontinue the use of the therapeutic level of medicated feed.
  4. Do not use in feeds containing pellet binding agents. (Required on premix and supplement labels only)
  5. Do not feed to animals other than swine.
  6. Do not feed undiluted. (Required on premix and supplement labels only)
  7. Swine being treated with tiamulin should not have access to or be treated with tiamulin incompatible polyether ionophores (for example monensin, lasalocid, salinomycin, narasin and semduramicin).
  8. For use in swine feed only.
  9. Do not feed to gilts and sows during 4 weeks after service.

Note (required to appear on medicated feed labels)

  1. Use as the only source of tiamulin.
  2. During treatment, swine should be housed under conditions of adequate space and sanitation.

Claim 2

For the treatment of swine dysentery associated with Brachyspira hyodysenteriae susceptible to tiamulin.

Level of medicating ingredient in a complete feed

178.1 mg/kg (0.01781%) of tiamulin base in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed as the sole ration for 14 days.

Additional information (not to appear on feed labels)

For feed manufacturers

Add and thoroughly mix into the ration at the following rate to provide 178.1 mg/kg (0.01781%) tiamulin base per metric tonne (1000 kg) of finished (complete) feed:

Warning

  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this medicated feed at 178.1 mg/kg (0.01781%) of tiamulin base in the complete feed.
  2. When mixing, direct contact with the skin and eyes should be avoided by wearing impermeable rubber gloves and safety glasses. In case of accidental eye contact, irrigate the eyes thoroughly with clean running water immediately. Seek medical advice if irritation persists. When handling the product, inhalation of the dust must be avoided by wearing a disposable half-mask respirator. Contaminated clothing should be removed and any splashes on to the skin should be washed off immediately. Wash hands after use. In case of accidental ingestion, seek medical advice immediately and show the label to the physician. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Overdoses of tiamulin have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. In very rare cases, death has been reported.
  2. In rare cases, redness of the skin, primarily over the ham and underline, has been observed during medication.
  3. If signs of toxicity or redness of the skin occurs, promptly discontinue the use of the therapeutic level of medicated feed.
  4. Do not use in feeds containing pellet binding agents. (Required on premix and supplement labels only)
  5. Do not feed to animals other than swine.
  6. Do not feed undiluted. (Required on premix and supplement labels only)
  7. Swine being treated with tiamulin should not have access to or be treated with tiamulin incompatible polyether ionophores (for example monensin, lasalocid, salinomycin, narasin and semduramicin).
  8. For use in swine feed only.
  9. Do not feed to gilts and sows during 4 weeks after service.

Note (required to appear on medicated feed labels)

  1. Use as the only source of tiamulin.
  2. During treatment, swine should be housed under conditions of adequate space and sanitation.

Claim 3

For the treatment of Porcine Colonic Spirochaetosis (colitis) associated with Brachyspira pilosicoli.

Level of medicating ingredient in a complete feed

178.1 mg/kg (0.01781%) of tiamulin base in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed as the sole ration for 14 days.

Additional information (not to appear on feed labels)

For feed manufacturers

Add and thoroughly mix into the ration at the following rate to provide 178.1 mg/kg (0.01781%) tiamulin base per metric tonne (1000 kg) of finished (complete) feed:

Warning

  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this medicated feed at 178.1 mg/kg (0.01781%) of tiamulin base in the complete feed.
  2. When mixing, direct contact with the skin and eyes should be avoided by wearing impermeable rubber gloves and safety glasses. In case of accidental eye contact, irrigate the eyes thoroughly with clean running water immediately. Seek medical advice if irritation persists. When handling the product, inhalation of the dust must be avoided by wearing a disposable half-mask respirator. Contaminated clothing should be removed and any splashes on to the skin should be washed off immediately. Wash hands after use. In case of accidental ingestion, seek medical advice immediately and show the label to the physician. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Overdoses of tiamulin have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. In very rare cases, death has been reported.
  2. In rare cases, redness of the skin, primarily over the ham and underline, has been observed during medication.
  3. If signs of toxicity or redness of the skin occurs, promptly discontinue the use of the therapeutic level of medicated feed.
  4. Do not use in feeds containing pellet binding agents. (Required on premix and supplement labels only)
  5. Do not feed to animals other than swine.
  6. Do not feed undiluted. (Required on premix and supplement labels only)
  7. Swine being treated with tiamulin should not have access to or be treated with tiamulin incompatible polyether ionophores (for example monensin, lasalocid, salinomycin, narasin and semduramicin).
  8. For use in swine feed only.
  9. Do not feed to gilts and sows during 4 weeks after service.

Note (required to appear on medicated feed labels)

  1. Use as the only source of tiamulin.
  2. During treatment, swine should be housed under conditions of adequate space and sanitation.

Claim 4

For the treatment of Porcine Proliferative Enteropathy (ileitis) caused by Lawsonia intracellularis.

Level of medicating ingredient in a complete feed

121.4 mg/kg (0.01214%) of tiamulin base in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed as the sole ration for 14 days.

Additional information (not to appear on feed labels)

For feed manufacturers

Add and thoroughly mix into the ration at the following rate to provide 121.4 mg/kg (0.01214%) tiamulin base per metric tonne (1000 kg) of finished (complete) feed:

Warning

  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this medicated feed at 121.4 mg/kg (0.01214%) of tiamulin base in the complete feed.
  2. When mixing, direct contact with the skin and eyes should be avoided by wearing impermeable rubber gloves and safety glasses. In case of accidental eye contact, irrigate the eyes thoroughly with clean running water immediately. Seek medical advice if irritation persists. When handling the product, inhalation of the dust must be avoided by wearing a disposable half-mask respirator. Contaminated clothing should be removed and any splashes on to the skin should be washed off immediately. Wash hands after use. In case of accidental ingestion, seek medical advice immediately and show the label to the physician. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Overdoses of tiamulin have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. In very rare cases, death has been reported.
  2. In rare cases, redness of the skin, primarily over the ham and underline, has been observed during medication.
  3. If signs of toxicity or redness of the skin occurs, promptly discontinue the use of the therapeutic level of medicated feed.
  4. Do not use in feeds containing pellet binding agents. (Required on premix and supplement labels only)
  5. Do not feed to animals other than swine.
  6. Do not feed undiluted. (Required on premix and supplement labels only)
  7. Swine being treated with tiamulin should not have access to or be treated with tiamulin incompatible polyether ionophores (for example monensin, lasalocid, salinomycin, narasin and semduramicin).
  8. For use in swine feed only.
  9. Do not feed to gilts and sows during 4 weeks after service.

Note (required to appear on medicated feed labels)

  1. Use as the only source of tiamulin.
  2. During treatment, swine should be housed under conditions of adequate space and sanitation.

Claim 5

For the treatment of Enzootic Pneumonia caused by Mycoplasma hyopneumoniae.

Level of medicating ingredient in a complete feed

133.5 mg/kg (0.01335%) of tiamulin base in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed as the sole ration for 14 days.

Additional information (not to appear on feed labels)

For feed manufacturers

Add and thoroughly mix into the ration at the following rate to provide 133.5 mg/kg (0.01335%) tiamulin base per metric tonne (1000 kg) of finished (complete) feed:

Warning

  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this medicated feed at 133.5 mg/kg (0.01335%) of tiamulin base in the complete feed.
  2. When mixing, direct contact with the skin and eyes should be avoided by wearing impermeable rubber gloves and safety glasses. In case of accidental eye contact, irrigate the eyes thoroughly with clean running water immediately. Seek medical advice if irritation persists. When handling the product, inhalation of the dust must be avoided by wearing a disposable half-mask respirator. Contaminated clothing should be removed and any splashes on to the skin should be washed off immediately. Wash hands after use. In case of accidental ingestion, seek medical advice immediately and show the label to the physician. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Overdoses of tiamulin have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. In very rare cases, death has been reported.
  2. In rare cases, redness of the skin, primarily over the ham and underline, has been observed during medication.
  3. If signs of toxicity or redness of the skin occurs, promptly discontinue the use of the therapeutic level of medicated feed.
  4. Do not use in feeds containing pellet binding agents. (Required on premix and supplement labels only)
  5. Do not feed to animals other than swine.
  6. Do not feed undiluted. (Required on premix and supplement labels only)
  7. Swine being treated with tiamulin should not have access to or be treated with tiamulin incompatible polyether ionophores (for example monensin, lasalocid, salinomycin, narasin and semduramicin).
  8. For use in swine feed only.
  9. Do not feed to gilts and sows during 4 weeks after service.

Note (required to appear on medicated feed labels)

  1. Use as the only source of tiamulin.
  2. During treatment, swine should be housed under conditions of adequate space and sanitation.

Accepted Compatibilities

Tiamulin is compatible with the following drugs. In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For further details, refer to the MIB as indicated.

Tiamulin (swine)
Name of medicating ingredient MIB code Name of approved brand(s) Applicable claims
Chlortetracycline hydrochloride CTC
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 50 Chlortetracycline Premix
  3. Chlor 100 Granular Medicated Premix
  4. Deracin 22% Granular Premix
All claims
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