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Sulfadiazine and Trimethoprim (SZTM) – Medicating Ingredient Brochure

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Status: Veterinary prescription required for approved claims

Date of revision: March 2021

Table of approved species and claims
Approved livestock species Approved claim(s)
(abbreviated)Table note 1
Withdrawal time Name of approved brand(s)
  1. Treatment of infections
7 days (meat)
  1. Uniprim Oral Powder
  2. Uniprim Oral Granules


Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claim 1
  1. Uniprim Oral Powder
  2. Uniprim Oral Granules
  1. Sulfadiazine USP at 333 mg/g (33.3%)
  2. Trimethoprim USP at 67 mg/g (6.7%)

Claim 1

For the treatment of the following infections when caused by susceptible organisms:

Level of medicating ingredient in a complete feed

The dose of sulfadiazine and trimethoprim (granules or powder) for horses, ponies or foals is 3.75 g per 50 kg body weight daily.

Additional information (not to appear on feed labels)

For feed manufacturers

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently.

Treatment should be given once daily until 2-3 days after the animal becomes asymptomatic. The usual course of treatment is no longer than 7 consecutive days.

Additional information (not to appear on feed labels)

For feed manufacturers


  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug.
  2. Keep out of reach of children.


  1. Should not be administered to pregnant mares as the effects of this product, when used as recommended, have not been determined on the unborn foal.
Additional information to be added as a note to feed labels


  1. Sulfadiazine and trimethoprim (granules or powder) should not be used in horses showing marked liver parenchymal damage or blood dyscrasias, nor in those with a history of sulfonamide sensitivity.
  2. If the treated horse does not consume the medication in total, then parenteral or individual oral dosage with an alternative product should be considered.

Accepted Compatibilities


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