Avilamycin (AVI) - Medicating Ingredient Brochure

Revised April 2020

Table of approved species and claims

Approved livestock species	Approved claim(s) (abbreviated) Table Note 1	Withdrawal time	Name of approved brand(s)
Broiler chickens	Prevention of necrotic enteritis	0 days	Surmax Premix
Swine	Reduction in incidence and severity of post-weaning diarrhea	0 days	Surmax Premix

Table Note

Table Note 1

In order to be compliant with the Feeds Regulations, the complete claim must appear on the medicated feed label.

Return to table note 1  referrer

Broiler chickens

Table of approved claims and brands

Approved claims	Name of approved brand(s)	Drug concentration in DIN product
Claim 1	Surmax Premix	Avilamycin at 100 g/kg

Claim 1

For the prevention of necrotic enteritis caused by Clostridium perfringens in growing broiler chickens.

Level of medicating ingredient in a complete feed

15 to 30 mg/kg (0.0015 to 0.003%) of avilamycin in the complete feed.

Directions for use in a complete feed

This livestock feed contains an antibiotic that has yet to be categorized and hence is potentially medically important. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently.

This medicated feed containing avilamycin at 15 to 30 mg/kg (ppm) should be fed as the sole ration continuously for a period of 21 days during the period of risk of necrotic enteritis, as determined by the veterinarian.

Warning

1. No withdrawal period is required for broiler chickens when treated at the recommended dose of 15 to 30 mg/kg (ppm) for a period of 21 days during the period of risk of necrotic enteritis.
2. Do not use in feeds for laying hens.
3. Avoid inhalation, oral exposure, and direct contact with skin or eyes. Operators mixing and handling avilamycin should use protective clothing, impervious gloves, goggles, and an approved dust mask. Wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. If irritation persists, seek medical attention. (Required on premix and supplement labels only)
4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

1. Do not use in feeds containing pellet binding agents with the exception of calcium lignosulfate pellet binder. (Required on premix and supplement labels only)

Accepted Compatibilities

Avilamycin is compatible with the following drugs/drug combinations. In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For details, refer to the MIB as indicated.

Avilamycin (broiler chickens)

Name of medicating ingredient	MIB code	Name of approved brand(s)	Applicable claims
Narasin	NAR	Monteban 100 Premix	Claim 1
Narasin and Nicarbazin	NRNC	Maxiban Premix	All claims

Swine

Table of approved claims and brands

Approved claims	Name of approved brand(s)	Drug concentration in DIN product
Claim 1	Surmax Premix	Avilamycin at 100 g/kg

Claim 1

For the reduction in incidence and severity of post-weaning diarrhea associated with Escherichia coli in pigs. Avilamycin is to be used in pigs that are at risk of developing, but not yet showing clinical signs of, diarrhea in the presence of pathogenic E. coli.

Level of medicating ingredient in a complete feed

80 mg/kg (0.008%) of avilamycin in the complete feed.

Directions for use in a complete feed

This livestock feed contains an antibiotic that has yet to be categorized and hence is potentially medically important. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently.

This medicated feed containing avilamycin at 80 mg/kg (ppm) should be fed as the sole ration continuously for a period of up to 21 days post-weaning, and prior to the expected onset of post-weaning diarrhea, as determined by the veterinarian.

Warning

1. No withdrawal period is required for swine when treated at the recommended dose of 80 mg/kg (ppm) for a period of up to 21 days post-weaning.
2. Avoid inhalation, oral exposure, and direct contact with skin or eyes. Operators mixing and handling avilamycin should use protective clothing, impervious gloves, goggles, and an approved dust mask. Wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. If irritation persists, seek medical attention. (Required on premix and supplement labels only)
3. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

1. Do not use in feeds containing pellet binding agents with the exception of calcium lignosulfate pellet binder. (Required on premix and supplement labels only)
2. The effectiveness of avilamycin has only been demonstrated when avilamycin-medicated feed was offered before the onset of diarrhea. Use of avilamycin for the treatment of established cases of clinical diarrhea in weanling pigs has not been demonstrated.

Accepted Compatibilities

Nil